Top 10 Rarest Diseases

Tough none of us appreciate diseases and sicknesses; the tragedy is that we can’t escape from being a victim of it. Apart from the day to day common sicknesses patients have been seen suffering from certain disorders which have not ruins one’s life but at times also makes them pay their innocent lives. The dangerous ones are those few whose treatments are as rare as the abnormality. Down below is a list of top ten rarest diseases that have been diagnosed in one among millions.

Top Ten Rare Disease

Keep reading to update your familiarity with the diseases that have been counted as the rare diseases on earth.

1. Smallpox

Smallpox - Top Ten Rare Disease

Smallpox is the rarest disease caused by either of the two variants – Variola major and Variola minor. It is also known by the Latin name, Variola or Variola vera which means spotted. It is believed that smallpox was recognised as early as 10,000 BC. High fever, fatigue, and a rash with flat red sores over the body are its symptoms. Due to immunization throughout the glob it is said to be eradicated.

2. Dercum’s Disease

Dercum’s disease - Top Ten Rare Disease

Occurring just below the skin mainly on the upper legs, upper arms and trunks; Dercum’s Disease is one of the rare diseases that is accompanied by several painful lipomas, weakness, irritability and depression. Since the cause of the ailment is unknown till date, its diagnosis is carried out based on the physical findings and history of the patient. Affecting adults, it occurs in women more as compared to men.

3. Hutchinson-Gilford Progeria

Hutchinson-Gilford Progeria - Top Ten Rare Disease

Progeria also known as Hutchinson–Gilford Progeria Syndrome is the third rarest disease due to genetic disorder with symptoms of ageing at an early age. The disorder has very low incidences and occurs in an estimated 1 per 8 million live births.

4. Fields’ Disease

Fields’ Disease - Top Ten Rare Disease

With only two cases diagnosed, Field’s disease is another such an ailment which is listed in the records of most rare disease. Named after two twins, Catherine and Kirstie Fields from Wales it is a neuromuscular sickness exhibiting muscular degeneration. The extent of the disease is yet to find out as the twins are still alive, in their teens.

5. Fibro Dysplasia Ossificans Progressiva (FOP)

Fibrodysplasia Ossificans Progressiva (FOP) - Top Ten Rare Disease

Sometimes referred to as Stone Man Syndrome, Fibro dysplasia ossificans progressiva (FOP) is a disease of the connective tissue causing mutation of the body. With no known treatment for the illness it affects one in two million people.

6. Fatal Familial Insomnia

Familial Insomnia - Top Ten Rare Disease

Another illness that makes its presence among the list of rare diseases is fatal familial insomnia that is caused either by a mutation to the protein PrPC or by spontaneous development in patients with a non-inherited mutation variant. There is no known cure for this syndrome and worsen conditions by leading to hallucinations, confusional states and delirium. After the onset of the disease, the survival duration of suffers is maximum 18 months.

7. Von Hippel-Lindau (VHL)

Von Hippel-Lindau - Top Ten Rare Diseases

Said to affect one in 35,000 people, Von Hippel-Lindau is a genetic disorder where the patient suffers from tumours in various parts of the body with maximum of the swelling centring on the central nervous system. If not treated during early stage it can lead to heart fails, and cardiovascular disease.

8. Landau Kleffner Syndrome

A rare childhood neurological syndrome, Landau Kleffner syndrome is named after Frank Kleffner and William Landau – who diagnosed it in six children during 1957. Affecting the brain parts that control speech and comprehension, it is basically seen in children in between the age group of 3 and 7.  According to experts it is dominant among males and results in loss of language skills and clinical seizures. Speech therapy, medications and corticosteroids are few of the known cures.

9. Paraneoplastic Pemphigus (PNP)

Paraneoplastic Pemphigus - Top Ten Rare Disease

Though there are many types of pemphigus, paraneoplastic pemphigus is the rarest and most severe of all. In pemphigus autoantibodies form against desmoglein which causes blisters and turns them into sores.

10. Alien Hand Syndrome

Alien Hand Syndrome - Top Ten Rare Disease

Regarded as outcomes of stroke, tumour, brain surgery, infection, wrong medication and aneurysm; alien hand syndrome is a neurological disorder where the sufferer’s hand starts acting voluntarily without the consent of the person. The disease was first recognised in Germany in 1908 by the Kurt Goldstein, the preeminent German neuro-psychiatrist. Though the condition can be managed and controlled to a certain degree, there is no permanent treatment for it.

One thought on “Top 10 Rarest Diseases

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